Google Chrome has until recently been clashing with Symantec Endpoint Protection (SEP), making it impossible to run Chrome in sandbox mode. It was possible to disable sandbox mode by running chrome with the argument –no-sandbox. Ironic, really, considering both SEP and sandbox mode attempts to protect the user from malware.
On behalf of a company, which owns SEP licenses, I frequently check https://licensing.symantec.com/ for product updates. On September 17, 2008 Symantec published a new maintenance release, MR3.
After installing the MR3 release on top of my existing MR2 installation I found that Chrome would run in sandbox mode. The Chrome-compatible SEP software version 11.0.3001.2224.